The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. ex. Some numerals are expressed as "XNUMX".
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The original paper is in English. Non-English content has been machine-translated and may contain typographical errors or mistranslations. Copyrights notice
Lorsque nous utilisons un dispositif microfluidique programmable (PMD), nous devons laver une zone contaminée afin d'utiliser la puce pour d'autres expériences. Récemment, une nouvelle technique de lavage appelée Block-Flushing a été proposée. Block-Flushing lave la zone contaminée dans les PMD en utilisant des flux tampons. Dans le Block-Flushing, nous devons maintenir un flux tampon d'un port d'entrée à un port de sortie d'un PMD pendant une longue période pour dissoudre les contaminants résiduels. Ainsi, nous pouvons avoir besoin de beaucoup de fluides tampons et de temps de lavage même si la zone contaminée est petite. Un autre inconvénient de la méthode de lavage par Block-Flushing est tel que nous ne pouvons peut-être pas nettoyer complètement les contaminants résiduels au niveau des vannes par les seuls flux tampons. Pour résoudre les problèmes mentionnés ci-dessus, cet article propose une idée totalement nouvelle pour laver les PMD ; notre méthode n'utilise pas de flux tampons, mais lave la zone contaminée à l'aide de mélangeurs. En utilisant un mélangeur, nous pouvons dissoudre très efficacement les contaminants résiduels au niveau des vannes situées dans la zone du mélangeur. Dans cet article, nous proposons deux méthodes pour laver les PMD en utilisant des mélangeurs. La première méthode permet de laver toute la zone des copeaux en utilisant seulement quatre fois le temps d'un seul mélangeur 2x2. Nous proposons également la deuxième méthode qui est une heuristique pour réduire le nombre de vannes mobiles car les vannes peuvent s'user si elles sont utilisées plusieurs fois. Nous montrons également quelques résultats expérimentaux pour confirmer que la deuxième méthode peut effectivement diminuer le nombre de vannes utilisées.
Yifang BAO
KuanDeng (Beijing) Science And Technology Ltd.
Shigeru YAMASHITA
Ritsumeikan University
Bing LI
Technical University of Munich
Tsung-Yi HO
the Department of Computer Science of National Tsing Hua University
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Yifang BAO, Shigeru YAMASHITA, Bing LI, Tsung-Yi HO, "Mixer-Based Washing Methods for Programmable Microfluidic Devices" in IEICE TRANSACTIONS on Fundamentals,
vol. E105-A, no. 10, pp. 1385-1391, October 2022, doi: 10.1587/transfun.2021EAP1114.
Abstract: When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.
URL: https://global.ieice.org/en_transactions/fundamentals/10.1587/transfun.2021EAP1114/_p
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@ARTICLE{e105-a_10_1385,
author={Yifang BAO, Shigeru YAMASHITA, Bing LI, Tsung-Yi HO, },
journal={IEICE TRANSACTIONS on Fundamentals},
title={Mixer-Based Washing Methods for Programmable Microfluidic Devices},
year={2022},
volume={E105-A},
number={10},
pages={1385-1391},
abstract={When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.},
keywords={},
doi={10.1587/transfun.2021EAP1114},
ISSN={1745-1337},
month={October},}
Copier
TY - JOUR
TI - Mixer-Based Washing Methods for Programmable Microfluidic Devices
T2 - IEICE TRANSACTIONS on Fundamentals
SP - 1385
EP - 1391
AU - Yifang BAO
AU - Shigeru YAMASHITA
AU - Bing LI
AU - Tsung-Yi HO
PY - 2022
DO - 10.1587/transfun.2021EAP1114
JO - IEICE TRANSACTIONS on Fundamentals
SN - 1745-1337
VL - E105-A
IS - 10
JA - IEICE TRANSACTIONS on Fundamentals
Y1 - October 2022
AB - When we use a Programmable Microfluidic Device (PMD), we need to wash some contaminated area to use the chip for further experiments. Recently, a novel washing technique called Block-Flushing has been proposed. Block-Flushing washes contaminated area in PMDs by using buffer flows. In Block-Flushing, we need to keep a buffer flow from an input port to an output port of a PMD for a long period to dissolve residual contaminants. Thus, we may need a lot of buffer fluids and washing time even if the contaminated area is small. Another disadvantage of the washing method by Block-Flushing is such that we may not able to clean residual contaminants at valves completely by only buffer flows. To address the above-mentioned issues, this paper proposes a totally new idea to wash PMDs; our method does not use buffer flows, but washes contaminated area by using mixers. By using a mixer, we can dissolve residual contaminants at valves in the area of the mixer very efficiently. In this paper, we propose two methods to wash PMDs by using mixers. The first method can wash the whole chip area by using only four times of a single 2x2-mixer time. We also propose the second method which is a heuristic to reduce the number of moving valves because valves may wear down if they are used many times. We also show some experimental results to confirm that the second method can indeed decrease the number of used valves.
ER -